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Dr Pamela Mason, a pharmacist with a special interest in nutrition, told The Journal on April 17 that the Department of Health had set up an expert group on intakes of vitamins and minerals that would report its findings in 2001 but had made no recommendations, yet.

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Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide.

Losartan pharmacokinetics have been investigated in the elderly (65 to 75 years) and in both genders.

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Treatment with Losartan also reduced the occurrence of sustained doubling of serum creatinine by 25% and ESRD by 29% as separate endpoints, but had no effect on overall mortality (see Table 4).

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It would be refreshing to find recommendations by chiropractors for all chiropractors to stop treating infant colic with spinal manipulation, or by acupuncturists for all acupuncturists to stop needling a certain acupuncture point because it had been tested and shown not to correspond to the organ they once thought it did, or by homeopaths for all homeopaths to stop using Oscillococcinum because no such organism ever existed.

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Frederick J. Zimmerman, an assistant professor at the Child Health Institute of the University of Washington, said the study raises important issues.

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The trial was supported by the by U01 grants from the NHLBI (HL068269, HL068270, HL068279, HL068281, HL068285, HL068292, HL068290, HL068288, HL085057) and the FDA Office of Orphan Products Development.

Similar outcomes have been reported with losartan potassium.

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Hydrochlorothiazide has been shown to have an additive effect (see CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects, Hypertension).

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Thus, telmisartan, a newer angiotensin receptor blocker, is a very useful addition to our armamentarium for the management of patients with mild-to-moderate hypertension and an important alternative as first-line treatment of this disease.

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In the Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan (RENAAL) study involving 1513 patients treated with Losartan or placebo, the overall incidences of reported adverse events were similar for the two groups.

Food and Drug Administration (FDA) are losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), candesartan (Atacand) and telmisartan (Micardis).

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As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function have been reported in susceptible individuals treated with losartan potassium; in some patients, these changes in renal function were reversible upon discontinuation of therapy.

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